Restores Metabolic Balance and
Supports Healthy Body Weight
About Dyglomera® and DygloFit®
Research has linked stubborn weight gain and obesity to a combination of factors: genes that favor the storage of excess body fat, unhealthy diets, and increasingly sedentary lifestyles. Together, these factors can disrupt metabolic balance, creating barriers to weight loss and posing serious health risks.
Dyglomera and DygloFit are trademarked brands of a patented extract of African spice fruit (Dichrostachys glomerata or DG). Clinical research shows that DG can restore metabolic balance to support healthy weight loss and cardiovascular health.
DG works through complementary mechanisms to modulate hormones, including GLP-1, insulin, leptin, and adiponectin, and to reduce oxidative stress. These actions are all linked to effective weight management.
Recommended adult daily serving: 400 mg. Suitable for a broad range of food, beverage and supplement product formats and applications.
Six Clinical
Studies
GRAS-affirmed
Kosher,
Halal
Vegan, Vegetarian,
Non-GMO
Water
Extraction
How Dichrostachys glomerata (DG) Works
DG works through complementary mechanisms to support metabolic wellness and healthy body weight and composition.
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Increases GLP-1, a peptide hormone known for its role in stimulating insulin release following meal consumption, which helps maintain stable blood sugar, reduce hunger, and promote satiety.
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Restores sensitivity to leptin and adiponectin, hormones that regulate satiety and appetite.
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Increases insulin sensitivity to help the body convert sugar into energy instead of storing it as fat.
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Fights free radicals to reduce oxidative stress and maintain cellular health.
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Maintains healthy levels of cholesterol, triglyceride and fast-blood sugar.
Clinical Research
Extensive clinical research supports the safety and efficacy of DG. Ten peer-reviewed studies, including six clinical trials involving over 600 subjects, have provided comprehensive safety and toxicology data.
In a recent randomized, double-blind, placebo-controlled clinical study, 90 overweight or obese subjects (BMI 25-30) consumed 400 mg of DG, 300 mg of Cissus quadrangularis (CQR-300®) or a placebo daily for 12 weeks. Measurements were taken at four, eight and 12 weeks to assess the effects of supplementation on body weight, BMI, body fat, GLP-1 levels, blood lipids, and fasting blood glucose.
The DG group demonstrated statistically significant improvements in all measures at each time point. After 12 weeks, the DG group achieved the following results.
Source: Cissus quadrangularis (CQR-300®) and Dichrostachys glomerata (Dyglomera®) extracts increase GLP-1 and inhibit DPP-4 in overweight and obese adults. Presentation abstract, 32nd International Conference of the Function Food Center, October 2024.
Compelling Structure/Function Claims*
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Supports healthy body weight & composition
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Restores metabolic balance and wellness
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Increases satiety/appetite control
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Supports cardiovascular health
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Helps maintain healthy cholesterol & blood sugar/pressure levels
Clinical Studies
Cissus quadrangularis (CQR-300®) and Dichrostachys glomerata (Dyglomera®) extracts increase GLP-1 and inhibit DPP-4 in overweight and obese adults. Presentation abstract, 32nd International Conference of the Function Food Center, October 2024.
The effects of Dyglomera® (Dichrostachys glomerata extract) on body fat percentage and body weight: a randomized, double-blind, placebo-controlled clinical trial. Functional Foods in Health and Disease, 2023.
The Effect of Extracts of Irvingia gabonensis (IGOB131) and Dichrostachys glomerata (Dyglomera™) on Body Weight and Lipid Parameters of Healthy Overweight Participants. Functional Foods in Health and Disease. 2015.
Anti-inflammatory, Anthropometric and Lipomodulatory Effects Dyglomera® (Aqueous Extract of Dichrostachys glomerata) in Obese Patients with Metabolic Syndrome. Functional Foods in Health and Disease. 2013.
Effectiveness of Dichrostachys glomerata Spice Phenolics in Reduction of Oxidative Stress Associated with Obesity and Type 2 Diabetes; a Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Journal of Food Research. 2013.
Effects of Dichrostachys glomerata Spice on Cardiovascular Diseases Risk Factors in Normoglycemic and Type 2 Diabetic Obese Volunteers. Food Research International. 2011.
Preclinical/Safety-Toxicology Studies
Anti-Obesity Effect of Dyglomera® Is Associated with Activation of the AMPK Signaling Pathway in 3T3-L1 Adipocytes and Mice with High-Fat Diet-Induced Obesity. Molecules. 2022.
Toxicologic Evaluation of Dichrostachys glomerata Extract: Subchronic Study in Rats and Genotoxicity Tests. Food and Chemical Toxicology. 2014.
Anti-amylase, Anti-lipase and Antioxidant Effects of Aqueous Extracts of Some Cameroonian Spices. Journal of Natural Products. 2010.
Antioxidant Characteristics of Dichrostachys glomerata Spice Extracts. CyTA - Journal of Food. 2010.
*This website is intended to provide scientific and educational information only. These statements have not been evaluated by the U.S. Food and Drug Administration nor any other regulatory agency in any country. Manufacturers should consult with their legal counsel to confirm the appropriateness of claim language in their respective region.
