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Naturally Supports Healthy Weight Management, Cardiovascular Health and Metabolic Wellness
About Cissus CQR-300®
CQR-300 is a patented extract of Cissus quadrangularis, an indigenous plant of India, Asia and West Africa long used in traditional medicine. It also contains cholesterol-lowering phytosterols and naturally occurring vitamin C, vitamin A and calcium.
The biologically active components of Cissus quadrangularis support numerous health benefits, including weight loss, heart health and metabolic wellness. Five peer-reviewed, placebo-controlled clinical studies with 475 subjects consistently demonstrated that CQR-300 significantly reduced body weight, percentage body fat and waist and hip circumference in 6 to 8 weeks.
Recommended adult daily serving: 300 mgs. Ideal for capsules, tablets, powdered mixes and beverages, as well as numerous other dietary supplement applications.
How Cissus CQR-300 Works
Preclinical research shows that CQR-300 naturally inhibits select enzymes (lipase, a-amylase, a-glucosidase) critical to the digestion and absorption of fat and carbohydrates. Together with a healthy diet and exercise, CQR-300 helps individuals achieve and maintain their body weight goals.
A randomized, double-blind, placebo-controlled study involving 67 overweight adults ages 25-60 was conducted over eight weeks to evaluate the efficacy of 300 mgs of CQR-300 daily in reducing the percentage of body fat. Multiple baseline and post-study weight and fat measurements were taken, including body imaging with dual-energy X-ray absorption (DEXA), the gold standard for assessing body fat percentages.
After eight weeks, the CQR-300 group:
Lost an average of 16.3 pounds, compared with 1.3 pounds for the placebo group.*
Reduced body fat 12.8% as measured by DEXA, compared with 0.3% gain in body fat in the placebo group.*
Trimmed waist circumference 8.9%, compared with a 1.6% reduction in the control group.*
Reduced hip circumference 7.7%, compared with a 1.8% decrease in the placebo group.*
Experienced statistically significant improvements in blood pressure, total cholesterol, triglycerides and leptin and adiponectin, two hormones that help regulate satiety, appetite and metabolism.*
Source: Journal of Alternative and Complementary Medicine, 2019.
The Use of a Stem and Leaf Aqueous Extract of Cissus quadrangularis (CQR-300) to Reduce Body Fat and Other Components of Metabolic Syndrome in Overweight Participants. The Journal of Alternative and Complementary Medicine. 2019.
The Use of Cissus quadrangularis (CQR-300) in the Management of Components of Metabolic Syndrome in Overweight and Obese Participants. Natural Product Communications. 2015.
The Use of a Cissus quadrangularis/Irvingia gabonensis Combination in the Management of Weight Loss: a Double-blind, Placebo-controlled Study. Lipids in Health and Disease. 2008.
The Effect of Cissus quadrangularis (CQR-300) and a Cissus Formulation (CORE) on Obesity and Obesity-induced Oxidative Stress. Lipids in Health and Disease. 2007.
The Use of a Cissus quadrangularis Formulation in the Management of Weight Loss and Metabolic Syndrome. Lipids in Health and Disease. 2006.
Preclinical Research/Safety-Tox Studies
Safety Assessment of Cissus quadrangularis Extract (CQR-300): Subchronic Toxicity and Mutagenicity Studies. Food and Chemical Toxicology. 2011.
Inhibitory Effects of Cissus quadrangularis L. Derived Components on Lipase, Amylase and α-Glucosidase Activity in vitro. Natural Products Communication. 2007.
*This website is intended to provide scientific and educational information only. These statements have not been evaluated by the U.S. Food and Drug Administration nor any other regulatory agency in any country. Manufacturers should consult with their legal counsel to confirm the appropriateness of claim language in their respective region.
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